Effect of Detoxification on Liver Stiffness Assessed by Fibroscan® in Alcoholic Patients
Effect of Detoxification on Liver Stiffness Assessed by Fibroscan® in Alcoholic Patients
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DOI：
10.1111/j.1530-0277.2010.01374.x
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发表时间：
2011-03-01
影响因子：
3.2
通讯作者：
Tran, Albert
中科院分区：
文献类型：
--
作者：
Gelsi, Eve;Dainese, Raphaella;Tran, Albert
目的：本研究的目的是确定是否饮酒或停止影响瞬态弹性成像（TE）测量和TE是否是一个有用的工具，以监测alcoholic patients.Patients：23个连续的重度饮酒者（20名男性和3名女性，平均年龄47.2岁）承认为7天的住院酒精解毒。入院时（DO），采集详细病史，并进行以下实验室检查[天冬氨酸转氨酶（ASAT）、γ谷氨酰转移酶（γ GT）和碳水化合物缺乏型转铁蛋白（CDT）水平和Fibrosca（R）]。在D8、D30和D 60重复所有检查。结果：脱毒1周后，TE的%变化为-21.67 +/-27.6%。D8和D 60之间TE的中位变化在戒断组中为-20%，在复发组中为32%（p = 0.007）。观察到TE显著降低的患者比例随着禁欲持续时间的增加而增加：D8时为41.7%，D 60时为66.7%。TE值与DO和D8时的ASAT、γ GT和CDT显著相关，与D 60时的ASAT和γ GT显著相关。结论：酒精中毒者的TE受疾病生化活动的主要变化的影响。TE的变化动力学表明，这种方法可能是有用的，以评估酒精滥用和控制。
Aims: The aims of this study were to determine whether alcohol consumption or cessation influences transient elastography (TE) measurements and whether TE is a useful tool to monitor alcoholic patients.Patients: Twenty-three consecutive heavy drinkers (20 men and 3 women; mean age 47.2 years) admitted for a 7-day hospitalization for alcohol detoxification were included. On admission (DO), a detailed medical history was taken and the following laboratory tests were performed [aspartate aminotransferase (ASAT), gamma glutamyltransferase (gamma GT), and carbohydrate-deficient transferrin (CDT) levels, and Fibrosca (R)]. All examinations were repeated on D8, D30, and D60. Variation in the median Fibroscan value of > 20% was considered significant.Results: After 1 week of detoxification, the % variation in TE was -21.67 +/- -27.6%. The median variation in TE between D8 and D60 was -20% in the abstinent group and 32% in the relapse group (p = 0.007). An increase in proportion of patients with a significant decrease in TE was observed with an increased duration of abstinence: 41.7% at D8 and 66.7% at D60. TE values were significantly correlated with ASAT, gamma GT, and CDT at DO and D8, and with ASAT and gamma GT at D60.Conclusions: TE in alcoholics is influenced by major variations in the biochemical activity of the disease. The kinetics of variation of TE suggest that this method may be useful to assess alcohol abuse and control.