solarius: an R interface to SOLAR for variance component analysis in pedigrees
solarius: an R interface to SOLAR for variance component analysis in pedigrees
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DOI：
10.1093/bioinformatics/btw080
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发表时间：
2016-06-15
期刊：
影响因子：
5.8
通讯作者：
Manuel Soria, Jose
中科院分区：
文献类型：
--
作者：
Ziyatdinov, Andrey;Brunel, Helena;Manuel Soria, Jose
摘要：开源环境 R 是使用最广泛的统计计算软件之一。它提供了包括统计遗传学在内的各种应用。大多数用于定量遗传分析的强大工具都是由学术界研究人员开发的独立免费程序。 SOLAR 是标准软件程序之一，用于对任意大小和复杂程度的谱系中的数量性状基因座 (QTL) 进行连锁和关联映射。 Solarius 允许用户利用 SOLAR 中实现的方差分量方法。它可以自动执行格式化谱系和表型数据等常规操作。它还解析模型输出，并包含用于探索结果的摘要和绘图函数。此外，solaius 还可以并行计算连锁和关联分析，从而使全基因组扫描的计算更加高效。
A Summary: The open source environment R is one of the most widely used software for statistical computing. It provides a variety of applications including statistical genetics. Most of the powerful tools for quantitative genetic analyses are stand-alone free programs developed by researchers in academia. SOLAR is one of the standard software programs to perform linkage and association mappings of the quantitative trait loci (QTLs) in pedigrees of arbitrary size and complexity. solarius allows the user to exploit the variance component methods implemented in SOLAR. It automates such routine operations as formatting pedigree and phenotype data. It parses also the model output and contains summary and plotting functions for exploration of the results. In addition, solarius enables parallel computing of the linkage and association analyses that makes the calculation of genome-wide scansmore efficient.