Mixed-effects and fMRI studies
Mixed-effects and fMRI studies
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DOI：
10.1016/j.neuroimage.2004.08.055
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发表时间：
2005-01-01
期刊：
影响因子：
5.7
通讯作者：
Kiebel, S
中科院分区：
文献类型：
--
作者：
Friston, KJ;Stephan, KE;Kiebel, S
本文涉及多期功能磁共振成像（fMRI）研究中的混合效应（MFX）分析。它阐明了混合效应分析和两阶段“汇总统计”程序之间的关系（Holmes，A.P.，弗里斯顿，K.J.，1998.概括性、随机效应和总体推断。NeuroImage 7，S754），已被广泛采用的功能磁共振成像数据在组水平的分析。我们描述了一个简单的程序，基于限制最大似然（ReML）估计的协方差分量，使充分的混合效应分析的背景下，统计参数映射。使用这个程序，我们比较了一个完整的混合效应分析的结果与那些从简单的两阶段的程序和评论的情况下，当两种方法可能会得到不同的结果。(C)2004年爱思唯尔公司All rights reserved.
This note concerns mixed-effect (MFX) analyses in multisession functional magnetic resonance imaging (fMRI) studies. It clarifies the relationship between mixed-effect analyses and the two-stage "summary statistics" procedure (Holmes, A.P., Friston, K.J., 1998. Generalisability, random effects and population inference. NeuroImage 7, S754) that has been adopted widely for analyses of fMRI data at the group level. We describe a simple procedure, based on restricted maximum likelihood (ReML) estimates of covariance components, that enables full mixed-effects analyses in the context of statistical parametric mapping. Using this procedure, we compare the results of a full mixed-effects analysis with those obtained from the simpler two-stage procedure and comment on the situations when the two approaches may give different results. (C) 2004 Elsevier Inc. All rights reserved.