Improvement of electroacupuncture on APP/PS1 transgenic mice in behavioral probably due to reducing deposition of Aβ in hippocampus
Improvement of electroacupuncture on APP/PS1 transgenic mice in behavioral probably due to reducing deposition of Aβ in hippocampus
复制标题
电针对 APP / PS1 转基因小鼠行为的改善可能是由于减少了海马中 Aβ 的沉积
DOI：
10.1002/ar.24737
复制
发表时间：
2021-09-01
影响因子：
2
通讯作者：
Wang, Xin
中科院分区：
文献类型：
--
作者：
Sun, Run-Quan;Wang, Zi-Dong;Wang, Xin
阿尔茨海默病（AD）是一种致命的神经退行性疾病，目前尚无治愈方法。电针作为一种治疗神经系统疾病的替代方法在我国已得到广泛应用。据报道，AD患者的认知能力下降与大脑海马中淀粉样蛋白β（A β）的沉积密切相关，Morris水迷宫（MWM）试验是一种广泛使用的评估动物模型行为的方法。本研究采用MWM测试评价电针对认知功能和记忆的影响，采用微区正电子发射断层扫描（micro-positron emission tomography，MECT）评价电针对海马A β沉积的影响。结果表明，与AD组相比，EA组APP/PS1小鼠的认知功能显著改善，[18 F]AV-45摄取率降低。本研究提示电针可能通过改善空间学习记忆和抑制海马A β沉积而发挥治疗作用。
Alzheimer's disease (AD) is a fatal neurodegenerative disease for which currently no cure is available. Electroacupuncture (EA) has been widely used in China as an alternative therapeutic approach for neurological diseases. The cognitive decline in patients with AD has been reported to be closely related to the deposition of amyloid-beta (A beta) in the hippocampus of the brain, and the Morris water maze (MWM) test is a widely used method for assessing the behavior of animal models. In this study, the MWM test was performed to evaluate the effects of EA treatment on cognitive function and memory, and the micro-positron emission tomography scan was used to assess the hippocampal A beta deposition. The results showed that the cognitive function of APP/PS1 mice was significantly improved and the rate of [18F]AV-45 uptake was reduced in the EA group, compared with the AD group. Our study suggested that EA can exert a therapeutic effect in AD by improving spatial learning and memory and inhibiting the hippocampal A beta deposition.