Targeted for drug delivery
Targeted for drug delivery
复制标题
DOI：
10.1016/s1369-7021(05)71033-6
复制
发表时间：
2005-08-01
期刊：
影响因子：
24.2
通讯作者：
Saltzman, W. Mark
中科院分区：
文献类型：
--
作者：
Fahmy, Tarek M.;Fong, Peter M.;Saltzman, W. Mark
靶向药物的概念并不新鲜，但可以追溯到1906年，当时Ehrlich(1)首次提出了“魔弹”的假设。这一概念的持久性是其吸引力的一个强有力的迹象，但“魔弹”仍然是在诊所实施的一个挑战。挑战来自三个方面：找到针对特定疾病状态的合适靶点；找到一种有效治疗这种疾病的药物；找到一种方法，以稳定的形式将药物运送到特定部位，同时避免免疫原性和非特异性相互作用，有效地清除体内的外来物质。纳米颗粒作为活性药物的载体具有潜在的用途，并且当与靶向配体结合时，可能实现“灵丹妙药”的许多属性。这篇综述的重点是靶向药物递送，利用纳米颗粒作为一种方式，将配体偶联到纳米大小的载药载体上，作为一种潜在的手段，在感兴趣的部位提高药物的疗效。
The concept of targeted drugs is not new, but dates back to 1906 when Ehrlich(1) first postulated the 'magic bullet'. The durability of this concept is a strong indication of its appeal, but the 'magic bullet' continues to be a challenge to implement in the clinic. The challenge has been on three fronts: finding the proper target for a particular disease state; finding a drug that effectively treats this disease; and finding a means of carrying the drug in a stable form to specific sites while avoiding the immunogenic and nonspecific interactions that efficiently clear foreign material from the body. Nanoparticles are potentially useful as carriers of active drugs and, when coupled with targeting ligands, may fulfill many attributes of a 'magic bullet'. This review focuses on targeted drug delivery using nanoparticles as a modality that couples a ligand to a nanosized, drug-loaded vehicle as a potential means to achieve increased efficacy of a drug at the site of interest.