Attention deficit and hyperactivity disorder scores are elevated and respond to N-acetylcysteine treatment in patients with systemic lupus erythematosus.
Attention deficit and hyperactivity disorder scores are elevated and respond to N-acetylcysteine treatment in patients with systemic lupus erythematosus.
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DOI：
10.1002/art.37893
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发表时间：
2013-05
影响因子：
--
通讯作者：
Perl, Andras
中科院分区：
文献类型：
--
作者：
Garcia, Ricardo J.;Francis, Lisa;Dawood, Maha;Lai, Zhi-wei;Faraone, Stephen V.;Perl, Andras
探讨注意缺陷多动障碍（ADHD）是否可作为系统性红斑狼疮（SLE）患者神经精神疾病的标志和n -乙酰半胱氨酸（NAC）治疗的靶点。采用ADHD自我报告量表（ASRS）对49例SLE患者和46例匹配的健康对照者进行评估。24名SLE患者随机接受安慰剂，NAC剂量为2.4 gm/天，或NAC剂量为4.8 gm/天。在3个月治疗前、治疗期间和1个月洗脱期后，每月使用不列颠群岛狼疮评估组（BILAG）指数、系统性红斑狼疮疾病活动指数（SLEDAI）、疲劳评估量表（FAS）和ASRS评估疾病活动性。与对照组相比，SLE患者的认知/注意力不集中（ASRS A部分）、多动/冲动（ASRS B部分）和综合（总）ASRS评分（平均±SEM分别为17.37±1.03 [P = 3 × 10−7]、14.51±0.89 [P = 2 × 10−4]和31.92±1.74 [P = 8 × 10−7]）高于对照组（10.41±1.02、9.61±1.21和20.02±1.98）。ASRS A部分评分与SLEDAI （r = 0.53, P < 0.0001）、BILAG评分相关（r = 0.36, P = 0.011）。ASRS总分与SLEDAI评分（r = 0.45, P = 0.0009）和BILAG评分（r = 0.31, P = 0.025）也存在相关性。ASRS A部分（r = 0.73, P < 0.0001）、ASRS B部分（r = 0.47, P = 0.0006）、ASRS总分（r = 0.67, P < 0.0001）与FAS评分相关。与安慰剂组相比，NAC剂量为2.4 gm/d和4.8 gm/d的SLE患者ASRS总分降低（P = 0.037）。NAC剂量为2.4 gm/d （P = 0.001）和4.8 gm/d （P < 0.0001）以及NAC剂量为2.4 gm/d和4.8 gm/d （P = 0.001）降低了ASRS部分A评分。在SLE患者中，ASRS评分升高揭示了NAC治疗有反应的先前未被识别的和临床显著的ADHD症状。
To investigate whether attention deficit hyperactivity disorder (ADHD) may serve as a marker of neuropsychiatric disease and as a target for N-acetylcysteine (NAC) treatment in patients with systemic lupus erythematosus (SLE). The ADHD Self-Report Scale (ASRS) was used to assess 49 patients with SLE and 46 matched healthy control subjects. Twenty-four of the patients with SLE were randomized to receive either placebo, NAC at a dosage of 2.4 gm/day, or NAC at a dosage of 4.8 gm/day. Disease activity was evaluated monthly using the British Isles Lupus Assessment Group (BILAG) index, the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), the Fatigue Assessment Scale (FAS), and the ASRS, before and during the 3-month treatment period and after a 1-month washout period. The cognitive/inattentive (ASRS part A), hyperactivity/impulsive (ASRS part B), and combined (total) ASRS scores were increased in patients with SLE compared with control subjects (mean ± SEM 17.37 ± 1.03 [P = 3 × 10−7], 14.51 ± 0.89 [P = 2 × 10−4], and 31.92 ± 1.74 [P = 8 × 10−7], respectively, versus 10.41 ± 1.02, 9.61 ± 1.21, and 20.02 ± 1.98, respectively. ASRS part A scores correlated with SLEDAI (r = 0.53, P < 0.0001) and BILAG scores (r = 0.36, P = 0.011). ASRS total scores also correlated with SLEDAI (r = 0.45, P = 0.0009) and BILAG scores (r = 0.31, P = 0.025). ASRS part A (r = 0.73, P < 0.0001), ASRS part B (r = 0.47, P = 0.0006), and ASRS total scores (r = 0.67, P < 0.0001) correlated with the FAS score. Relative to the scores in placebo-treated patients, ASRS total scores were reduced in SLE patients treated with NAC dosages of 2.4 gm/day and 4.8 gm/day combined (P = 0.037). ASRS part A scores were reduced by NAC dosages of 2.4 gm/day (P = 0.001) and 4.8 gm/day (P < 0.0001) as well as by NAC at dosages of 2.4 gm/day and 4.8 gm/day combined (P = 0.001). In patients with SLE, elevated ASRS scores reveal previously unrecognized and clinically significant symptoms of ADHD that respond to NAC treatment.
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影响因子：
--
作者：
Lai, Zhi-Wei;Hanczko, Robert;Bonilla, Eduardo;Caza, Tiffany N.;Clair, Brandon;Bartos, Adam;Miklossy, Gabriella;Jimah, John;Doherty, Edward;Tily, Hajra;Francis, Lisa;Garcia, Ricardo;Dawood, Maha;Yu, Jianghong;Ramos, Irene;Coman, Ioana;Faraone, Stephen V.;Phillips, Paul E.;Perl, Andras
通讯作者：
Perl, Andras
DOI：
10.1080/10401230600801077
发表时间：
2006-07-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Adler, Lenard A;Spencer, Thomas;Secnik, Kristina
通讯作者：
Secnik, Kristina
影响因子：
4.7
作者：
Michielsen, HJ;De Vries, J;Van Heck, GL
通讯作者：
Van Heck, GL
影响因子：
2.9
作者：
Martínez, M;Hernández, AI;Martínez, N
通讯作者：
Martínez, N
影响因子：
10.6
作者：
Berk, Michael;Copolov, David;Bush, Ashley I.
通讯作者：
Bush, Ashley I.