Genomic stability and instability: a working paradigm.
Genomic stability and instability: a working paradigm.
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基因组稳定性和不稳定性：工作范式。
DOI：
10.1007/978-3-642-60505-5_2
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发表时间：
1997
影响因子：
--
通讯作者：
Loeb,LA
中科院分区：
文献类型：
--
作者：
Cheng,KC;Loeb,LA
对突变本质的近一个世纪的科学探索，让我们对导致突变和推动进化的力量有了令人兴奋的一瞥。新概念使我们意识到每次细胞分裂时复制和分发精确的基因组副本的挑战的严重性。在人类一生中发生的1016个体细胞分裂中，每一个基因组的拷贝必须包含大约30亿个核苷酸碱基对的完整序列，每一个子细胞必须得到正确数量的46条染色体，这些染色体是生命说明书的组成部分。精确的DNA复制和分布这一具有挑战性的任务必须在细胞不断受到破坏DNA的力的攻击时完成。
Nearly a century of scientific inquiry into the nature of mutation has offered an exciting glimpse of the forces that cause mutation and drive evolution. New concepts make us realize the magnitude of the challenge of duplicating and distributing an accurate copy of the genome each time a cell divides. For each of the 1016somatic cell divisions that occur in a human lifetime, each copy of the genome must contain an intact sequence of some 3 billion nucleotide base pairs, and each daughter cell must receive the correct number of the 46 chromosomes into which the instruction book of life is parceled. The challenging task of accurate DNA replication and distribution must be accomplished while the cell is under constant attack by forces that damage DNA.