Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates.
Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates.
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DOI：
10.1210/jcem.81.11.8923837
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发表时间：
1996-11
期刊：
影响因子：
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通讯作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
中科院分区：
文献类型：
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作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
以重组人瘦素全长为标准，用放射免疫法测定了204例18~80岁正常体重和肥胖者的血浆瘦素水平。观察空腹水平在1.2-97.9 ng/mL之间。血浆瘦素浓度与体脂百分比高度相关(r=0.710；P<；0.0001)，女性为男性的3倍(17.1vs.5.8 ng/mL；P<；0.0001)。循环瘦素与年龄呈负相关，在60岁以上的受试者中下降了53%。包含体脂百分比、性别和年龄的统计模型解释了血浆瘦素水平变化的65%。瘦素与腹部脂肪分布、血脂和脂蛋白、慢性能量摄入、饮食结构、血浆胰岛素或最大耗氧量无关。然而，在5名肥胖受试者中，在食用1000卡饮食10天后，血浆瘦素下降了26%(P=0.004)。我们得出结论，随着肥胖程度的增加，循环中的瘦素持续升高。性别、年龄和短期热量限制可能是血浆瘦素的重要次级调节因素。
We measured plasma leptin concentrations by RIA in 204 normal weight and obese subjects, aged 18-80 yr, using full-length recombinant human leptin as a standard. Fasting levels between 1.2-97.9 ng/mL were observed. The plasma leptin concentration was highly correlated with percent body fat (r = 0.710; P < 0.0001) and was 3 times as high in women as in men (17.1 vs. 5.8 ng/mL; P < 0.0001). Circulating leptin was inversely related to age and was reduced 53% in subjects over age 60 yr. A statistical model containing percent body fat, gender, and age accounted for 65% of the variance in plasma leptin levels. Leptin was not independently related to abdominal fat distribution, plasma lipids and lipoproteins, chronic energy intake, diet composition, plasma insulin, or maximum oxygen consumption. However, plasma leptin was reduced by 26% in 5 obese subjects who consumed a 1000-Cal diet for 10 days (P = 0.004). We conclude that circulating leptin rises continuously with increasing adiposity. Gender, age, and short term caloric restriction may be important secondary regulators of plasma leptin.