Comparative study between topically applied irradiated human amniotic membrane in combination with tea tree oil versus topical tioconazole in pityraisis versicolor treatment
Comparative study between topically applied irradiated human amniotic membrane in combination with tea tree oil versus topical tioconazole in pityraisis versicolor treatment
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DOI：
10.1007/s10561-020-09824-5
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发表时间：
2020-06-01
影响因子：
1.5
通讯作者：
Nemr, Waleed A.
中科院分区：
文献类型：
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作者：
Nashwa, Radwan K.;Ahmed, El Bedewi;Nemr, Waleed A.
花斑糠疹（PV）是一种由皮肤相关酵母马拉色菌毒力活性引起的慢性皮肤病。传统上，噻康唑被用作治疗PV的局部抗真菌药。先前的研究指出，人类羊膜（HAM），胎盘组织，具有抗菌和抗炎活性，是愈合皮肤损伤的有用敷料。此外，茶树油（TTO）具有有效的抗真菌作用。该临床试验旨在实现一种替代治疗方法，即使用饱和tto的HAM （TOSHAM）杀死马拉色菌并治愈PV病变，且应用时间短。本研究纳入了120例色素沉着或色素沉着的PV病变患者；一半患者每周使用TOSHAM治疗，而其他患者每天使用1%噻康唑乳膏作为传统治疗。对TOSHAM与噻康唑的体外杀真菌活性进行了微生物学评价。本研究的临床结果证明，TOSHAM治疗PV病变的活性优于噻康唑；这与微生物学的发现是一致的。本研究探讨了一种新的PV治疗方法，通过使用TOSHAM获得了良好的效果。
Pityriasis versicolor (PV) is a chronic skin disease caused by virulence activities of Malassezia, a genus of skin-associated yeasts. Traditionally, Tioconazole is used as a topical antifungal for curing PV. Previous investigations cited that human amniotic membrane (HAM), a placental tissue, has antimicrobial and anti-inflammatory activities and is useful as a dressing for healing skin lesions. Moreover, tea tree oil (TTO) has a potent antifungal efficacy. This clinical trial aims to achieve an alternative therapeutic treatment able to kill Malassezia and heal PV lesions using TTO-saturated HAM (TOSHAM), with little application times. This study subjected 120 patients with hypopigmented or hyperpigmented PV lesions; half patients were treated weekly with TOSHAM compared with the others who applying 1% Tioconazole cream daily as a traditional treatment. Microbiological evaluation of in vitro fungicidal activity of TOSHAM versus Tioconazole was carried out against Malassezia furfur culture. The clinical outcomes of this study proved the superior activity of TOSHAM to heal PV lesions than Tioconazole; this was in harmony with microbiological findings. This study approached a novel therapeutic treatment of PV with great outcomes by using TOSHAM.