Vascular and parenchymal Aβ deposition in the aging dog:: correlation with behavior
Vascular and parenchymal Aβ deposition in the aging dog:: correlation with behavior
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DOI：
10.1016/s0197-4580(00)00113-5
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发表时间：
2000-09-01
影响因子：
4.2
通讯作者：
Duykaerts, C
中科院分区：
文献类型：
--
作者：
Colle, MA;Hauw, JJ;Duykaerts, C
通过主人填写的正式问卷(年龄相关认知和情感障碍评估-ARCAD)间接评估25只狗的行为。使用四种抗Aβ多肽抗体评估四个颞区弥漫性沉积和血管沉积的密度。除1只老年动物外，其余老年动物均可见弥漫性的Aβ42多肽沉积。刚果红阴性，抗Aβ40抗体不染色，与血管沉积相反。血管密度和实质沉积密度之间无相关性。ARCAD评分与年龄、Aβ实质和血管沉积的密度以及包含沉积的区域的数目(扩展指数)相关。多变量分析显示，年龄和延伸指数解释了大部分差异。刚果红阳性(表明Aβ肽具有淀粉样物质的特征)仅限于狗的血管壁，与人类一样，与Aβ1-40亚型的沉积有关。实质性Aβ沉积似乎是老年狗的行为问题的常见相关性。(C)2000 Elsevier Science Inc.保留所有权利。
The behavior of 25 dogs was indirectly assessed by a formal questionnaire (evaluation of Age-Related Cognitive and Affective Disorders-ARCAD), filled out by the owner. The density of diffuse and vascular deposits was evaluated using four anti-A beta peptide antibodies, in four temporal areas. Parenchymal, diffuse deposits of A beta 42 peptide were found in all aged animals but one. They were Congo red negative and were not immunostained by the anti-A beta 40 antibody, contrary to the vascular deposits. The densities of vascular and parenchymal deposits were not correlated. The ARCAD score was correlated with age, density of A beta parenchymal and vascular deposits, and with the number of areas containing deposits (extension index). Multivariate analysis showed that the age and the extension index explained most of the variance. Congo red positivity (indicating that the A beta peptide has the characteristics of an amyloid substance) is limited in the dog to the vascular wall and is associated, as in man, with the deposition of the A beta 1-40 isoform. Parenchymal A beta deposition seems to be a common correlate of behavioral problems in aging dogs. (C) 2000 Elsevier Science Inc. All rights reserved.