Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis.
Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis.
复制标题
树突核糖体表明动情突触发生期间存在局部蛋白质合成。
DOI：
10.1097/01.wnr.0000078380.40088.99
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Milner,TeresaA
中科院分区：
文献类型：
--
作者：
McCarthy,JBrian;Milner,TeresaA
海马CA1区放射层内突触数和树突棘数在动情周期内波动。动情期的突触发生阶段由雌激素驱动，可能需要新合成的蛋白质。核糖体在游离于细胞质中时合成可溶性蛋白质，而在膜结合时合成整合膜或分泌蛋白质。在这里，我们报告，核糖体免疫反应性和膜相关的百分比增加局部在树突的CA 1 stratul辐射在雌激素诱导的突触。这些发现与雌激素在调节整个动情周期中树突中新发育突触的膜蛋白（如受体）的局部合成中的作用一致。
Synapse number and dendritic spine number fluctuate across the estrous cycle in the hippocampal CAl stratum radiatum. The synaptogenesis phase of estrous is driven by estrogen and may require newly synthesized proteins. Ribosomes synthesize soluble proteins when free in the cytoplasm, and integral membrane or secretory proteins when membrane-associated. Here we report that ribosomal immunoreactivity and the percentage associated with membranes increases locally in dendrites of the CAl stratul radiatum during estrogen-induced synaptogenesis. These findings are consistent with a role for estrogen in regulating the local synthesis of integral membrane proteins, eg receptors, in dendrites for newly developing synapses across the estrous cycle.