Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction.
Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction.
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DOI：
10.1039/c3cc45449e
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发表时间：
2013-09
影响因子：
4.9
通讯作者：
Nana Zhang;Qingzhen Yu;Ru Chen;Jianhui Huang;Yeqing Xia;K. Zhao
中科院分区：
文献类型：
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作者：
Nana Zhang;Qingzhen Yu;Ru Chen;Jianhui Huang;Yeqing Xia;K. Zhao
开发了一种新型的钯催化C-H活化反应合成联芳亚氨基/酮基羧酸。该反应经历芳基酰胺指导的C-H活化邻位酰化，然后闭环和开环过程，得到一系列联芳基亚氨基/酮基羧酸。我们的方法的特点是利用廉价和绿色氧化剂（TBHP）以及容易获得的醛。
A novel Pd-catalysed C-H activation reaction for the synthesis of biaryl imino/keto carboxylic acids is developed. This reaction underwent aryl amide directed C-H activation ortho-acylation followed by ring closing and ring opening processes to give a range of biaryl imino/keto carboxylic acids. Our methodology features the utilization of a cheap and green oxidant (TBHP) as well as readily available aldehydes.