Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia
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DOI：
10.1016/j.jalz.2016.04.005
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发表时间：
2016-11-01
影响因子：
14
通讯作者：
Aarsland, Dag
中科院分区：
文献类型：
--
作者：
Bereczki, Erika;Francis, Paul T.;Aarsland, Dag
简介：我们的目的是比较参与突触传递不同步骤的三种突触蛋白：Rab3A、SNAP 25和神经颗粒素在三种常见形式的痴呆中的水平：阿尔茨海默病（AD）、路易体痴呆（DLB）和帕金森病痴呆。对129例死后人脑标本进行脑区域特异性分析，探讨其与形态学变化和认知功能下降的关系。我们已经观察到反映所有研究的痴呆组中突触功能障碍的强有力的变化。认知能力下降的速度与下顶叶DLB中Rab3和前额叶中AD中SNAP 25水平降低之间存在显著相关性。特别值得注意的是，突触蛋白显着区分痴呆症病例和控制90%以上的灵敏度和specificity.Discussion：我们的研究结果表明，突触标记物可以预测AD认知能力下降的命题，应扩展到路易体疾病。(C)2016年阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia.Methods: A total of 129 postmortem human brain samples were analyzed in brain regional specific manner exploring their associations with morphologic changes and cognitive decline.Results: We have observed robust changes reflecting synaptic dysfunction in all studied dementia groups. There were significant associations between the rate of cognitive decline and decreased levels of Rab3 in DLB in the inferior parietal lobe and SNAP25 in AD in the prefrontal cortex. Of particular note, synaptic proteins significantly discriminated between dementia cases and controls with over 90% sensitivity and specificity.Discussion: Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.