Effects of ethanol on the activity of brain enzymes.
Effects of ethanol on the activity of brain enzymes.
复制标题
乙醇对脑酶活性的影响。
DOI：
10.1159/000469242
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Liljequist
中科院分区：
文献类型：
--
作者：
B. Tabakoff;P. Hoffman;S. Liljequist
乙醇以选择性的方式改变中枢神经系统（CNS）中几种膜结合酶的活性，这些酶对于神经元的信息传递很重要。乙醇抑制 Na+/K+ 转运 ATP 酶活性，而体外添加的乙醇会刺激腺苷酸环化酶 (AC) 活性。乙醇对 AC 活性的影响主要是通过影响调节 AC 活性的蛋白质来介导的。乙醇对单胺氧化酶活性具有选择性作用，因为该酶的 B 形式对体外添加的乙醇的抑制更敏感。乙醇对不同膜结合中枢神经系统酶的选择性作用可能是由于酶的不同膜脂微环境或酶蛋白本身的差异造成的。
Ethanol alters, in a selective manner, the activity of several membrane-bound enzymes in the central nervous system (CNS) which are important for neuronal transmission of information. Ethanol inhibits Na+/K+-transporting ATPase activity, while adenylate cyclase (AC) activity is stimulated by ethanol added in vitro. Ethanol's effects on AC activity are mediated primarily via effects on proteins that regulate AC activity. Ethanol has selective effects on monoamine oxidase activity, in that the B form of the enzyme is more sensitive to inhibition by ethanol added in vitro. The selective effects of ethanol on different membrane-bound CNS enzymes may result from differing membrane lipid microenvironments of the enzymes, or from differences in the enzyme proteins per se.