MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study
MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study
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DOI：
10.1192/bjp.bp.110.086991
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发表时间：
2011-06-01
影响因子：
10.5
通讯作者：
Kennedy, Martin A.
中科院分区：
文献类型：
--
作者：
Fergusson, David M.;Boden, Joseph M.;Kennedy, Martin A.
背景最近的研究提出了涉及单胺氧化酶 A (MAOA) 基因的基因 x 环境 (G x E) 相互作用的可复制性问题，以调节虐待或虐待暴露与反社会行为之间的关联。本研究试图使用与原始研究队列非常相似的 30 年纵向研究来复制该领域的发现。目的是检验低活性 MAOA 基因型的存在与对滥用暴露的反应增加相关的假设。方法参与者是来自基督城健康与发展研究的 398 名男性，他们拥有以下方面的完整数据：MAOA 启动子区可变数量串联重复基因型； 30岁以下有反社会行为；结果使用童年时期遭受性虐待和身体虐待的衡量标准，将回归模型拟合到从 16 岁到 30 岁观察到的五种反社会行为结果（自我报告的财产犯罪；自我报告的暴力犯罪；财产/暴力犯罪定罪；行为问题；敌意）。分析揭示了 G x E 相互作用的一致证据，那些具有低活性 MAOA 变异且在童年时期遭受虐待的人更有可能报告后来的犯罪、行为问题和敌意。在控制了一系列潜在的混杂因素后，这些相互作用仍然具有统计学意义。定罪数据的结果有些较弱。 结论 目前的研究结果增加了证据，表明在整个生命过程中存在涉及 MAOA、虐待暴露和反社会行为的稳定的 G x E 相互作用。
BackgroundRecent studies have raised issues concerning the replicability of gene x environment (G x E) interactions involving the monoamine oxidase A (MAOA) gene in moderating the associations between abuse or maltreatment exposure and antisocial behaviour. This study attempted to replicate the findings in this area using a 30-year longitudinal study that has strong resemblance to the original research cohort.AimsTo test the hypothesis that the presence of the low-activity MAOA genotype was associated with an increased response to abuse exposure.MethodParticipants were 398 males from the Christchurch Health and Development Study who had complete data on: MAOA promoter region variable number tandem repeat genotype; antisocial behaviour to age 30; and exposure to childhood sexual and physical abuse.ResultsRegression models were fitted to five antisocial behaviour outcomes (self-reported property offending; self-reported violent offending; convictions for property/violent offending; conduct problems; hostility) observed from age 16 to 30, using measures of childhood exposure to sexual and physical abuse. The analyses revealed consistent evidence of G x E interactions, with those having the low-activity MAOA variant and who were exposed to abuse in childhood being significantly more likely to report later offending, conduct problems and hostility. These interactions remained statistically significant after control for a range of potentially confounding factors. Findings for convictions data were somewhat weaker.ConclusionsThe present findings add to the evidence suggesting that there is a stable G x E interaction involving MAOA, abuse exposure and antisocial behaviour across the life course.