HB-HIMEJI OR BETA-140(H18)ALA-]ASP - A SLIGHTLY UNSTABLE HEMOGLOBIN WITH INCREASED BETA-N-TERMINAL GLYCATION
HB-HIMEJI OR BETA-140(H18)ALA-]ASP - A SLIGHTLY UNSTABLE HEMOGLOBIN WITH INCREASED BETA-N-TERMINAL GLYCATION
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DOI：
10.3109/03630268609046438
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发表时间：
1986-01-01
期刊：
影响因子：
1
通讯作者：
IMAI, K
中科院分区：
文献类型：
--
作者：
OHBA, Y;MIYAJI, T;IMAI, K
在糖尿病患者中发现的快速移动的异常血红蛋白被鉴定为 .beta.140 (H18) Ala .fwdarw。天冬氨酸。它约占总血红蛋白的40%。据估计，异常血红蛋白中的βN-末端糖化程度是同一血液样本中Hb A 中的βN-末端糖化程度的3倍。异常血红蛋白稍微不稳定。剥离后的血红蛋白的氧亲和力下降，但由于2,3-二磷酸甘油酸的影响减弱，来自载体的红细胞的氧亲和力略高于正常。
A fast-moving abnormal hemoglobin found in a diabetic patient was identified as .beta.140 (H18) Ala .fwdarw. Asp. It comprised about 40% of the total hemoglobin. The .beta.N-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate.