Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa
Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa
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DOI：
10.1111/aos.12293
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发表时间：
2014-05-01
影响因子：
3.4
通讯作者：
Ishibashi, Tatsuro
中科院分区：
文献类型：
--
作者：
Akiyama, Masato;Ikeda, Yasuhiro;Ishibashi, Tatsuro
目的观察异丙乌诺前列酮（unoprostone isopropyl，unoprostone）治疗视网膜色素变性（retinitis pigmentosa，RP）的疗效。40例患者中有17例随机选择一只眼，每日两次局部使用0.12%乌诺前列酮。治疗后每3个月随访一次。通过使用Humphrey视野分析仪（HFA：中央10-2程序）的视力和视野测量测试来监测治疗的疗效。此外，12 RP患者被列入本研究和12名正常人进行了评估，他们的黄斑血流的双眼滴注后，乌诺前列酮使用的激光散斑method.Results1年后，“黄斑敏感性”，计算HFA的平均敏感性的中心12点，被保存在对方的眼睛，以及乌诺前列酮治疗的眼睛。另一方面，在对照RP患者的眼睛中，该值显著降低。此外，乌诺前列酮治疗眼的“黄斑敏感性”比对照眼有更大的改善。RP患者和正常人黄斑血流变化率在治疗眼和对侧眼均显著增加。没有严重的副作用observed.ConclusionsThese结果表明，局部乌诺前列酮可能有一个治疗效果RP患者的黄斑血流改善的后果，以及其直接的神经保护作用。
PurposeTo evaluate the therapeutic effect of topical unoprostone isopropyl (unoprostone) on patients with retinitis pigmentosa (RP).MethodsForty patients with typical forms of RP were included in the study. Seventeen of 40 patients were treated with 0.12% topical unoprostone twice daily in a randomly selected eye. Patients underwent follow-up examinations every 3months after treatment. The efficacy of the treatment was monitored by visual acuity and visual field measurement testing using the Humphrey Field Analyzer (HFA: the central 10-2 programme). Moreover, 12 RP patients who were included this study and 12 normal subjects were evaluated in terms of their macular blood flow of both eyes after instillation of unoprostone using the laser speckle method.ResultsOne year after treatment, the 'macular sensitivity', calculated by HFA as the average sensitivity of the central 12 points, was preserved in the fellow eyes as well as the unoprostone-treated eyes. On the other hand, that in the eyes of the control RP patient was significantly decreased. Moreover, there were significantly greater improvements of the 'macular sensitivity' in the unoprostone-treated eyes than the fellow eyes. The change ratios of macular blood flow obtained from both RP patients and normal subjects were significantly increased in both the treated and the fellow eyes. No severe side-effects were observed.ConclusionsThese results demonstrate that topical unoprostone might have a therapeutic efficacy in patients with RP as a consequence of the macular blood flow improvement as well as its direct neuroprotective effect.