Reconsolidation: maintaining memory relevance.
Reconsolidation: maintaining memory relevance.
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DOI：
10.1016/j.tins.2009.05.002
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发表时间：
2009-08
影响因子：
15.9
通讯作者：
Lee, Jonathan L C
中科院分区：
文献类型：
--
作者：
Lee, Jonathan L C
记忆的恢复将其置于可塑状态，因此记忆可以被破坏，甚至通过实验治疗来增强。这种现象已经在记忆被重新激活的框架内概念化，然后在重复的细胞处理中重新巩固。重新巩固阶段被认为是理解记忆稳定性的关键，最近被认为是治疗创伤后应激障碍和药物成瘾等疾病的潜在治疗靶点。然而，很少有人知道的再激活过程，也可能是什么样的自适应功能的检索诱导的可塑性。长期以来，重新巩固被认为是调节记忆更新的媒介，但直到最近，这一假设才得到实验支持。在这里，记忆再巩固的自适应功能进行了更详细的探讨，强调其在更新记忆，以保持其相关性的作用。
The retrieval of a memory places it into a plastic state, as a result of which the memory can be disrupted or even enhanced by experimental treatment. This phenomenon has been conceptualised within a framework of memories being reactivated and then reconsolidated in repeated rounds of cellular processing. The reconsolidation phase has been seized upon as critical for the understanding of memory stability, and more recently as a potential therapeutic target in the treatment of disorders such as post-traumatic stress and drug addiction. However, little is known about the reactivation process, nor what might be the adaptive function of retrieval-induced plasticity. Reconsolidation has long been proposed to mediate memory updating, but only recently has this hypothesis been supported experimentally. Here, the adaptive function of memory reconsolidation is explored in more detail, with a strong emphasis on its role in updating memories to maintain their relevance.