SICI during changing brain states: Differences in methodology can lead to different conclusions.
SICI during changing brain states: Differences in methodology can lead to different conclusions.
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DOI：
10.1016/j.brs.2019.11.002
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发表时间：
2020-03
影响因子：
7.7
通讯作者：
Rothwell JC
中科院分区：
文献类型：
--
作者：
Ibáñez J;Spampinato DA;Paraneetharan V;Rothwell JC
短潜伏期皮质内抑制（SICI）被广泛用于探索M1中gaba能抑制机制。SICI的任务相关变化被认为反映了gaba能通路中枢兴奋性的变化。通常，SICI的水平是用单一强度的条件反射刺激来评估的，这样就可以比较不同大脑状态下的抑制作用。在这里，我们表明这种方法有时可能是不充分的，因为如果使用不同的CS强度，可以得出不同的结论。我们在休息和警告的简单反应时间任务中使用一系列CS强度来测量SICI。我们的研究结果表明，在任务期间发生的SICI变化可能比静止时更大或更小，这取决于CS的强度。这些发现表明，当使用单一强度的CS来测量任务相关的生理变化时，需要仔细解释结果。我们在休息和警告的简单反应时间任务中使用几个条件刺激（CS）强度来测量SICI。运动前SICI的变化可以比静止时大或小，这取决于所使用的CS的强度。当使用单一CS强度来测量任务相关的生理变化时，需要仔细解释SICI。
Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of conditioning stimulus so that inhibition can be compared in different brain states. Here, we show that this approach may sometimes be inadequate since distinct conclusions can be drawn if a different CS intensity is used. We measured SICI using a range of CS intensities at rest and during a warned simple reaction time task. Our results show that SICI changes that occurred during the task could be either larger or smaller than at rest depending on the intensity of the CS. These findings indicate that careful interpretation of results are needed when a single intensity of CS is used to measure task-related physiological changes. We measured SICI using several conditioning stimulus (CS) intensities at rest and during a warned simple reaction time task. Pre-movement SICI changes can be either larger or smaller than at rest depending on the intensity of the CS used. Careful interpretation of SICI is needed when a single intensity of CS is used to measure task-related physiological changes.