Copper-catalyzed pyrrole synthesis from 3,6-dihydro-1,2-oxazines
Copper-catalyzed pyrrole synthesis from 3,6-dihydro-1,2-oxazines
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DOI：
10.1039/c8gc01373j
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发表时间：
2018-10
期刊：
影响因子：
9.8
通讯作者：
Naoki Yasukawa;Marina Kuwata;T. Imai;Y. Monguchi;H. Sajiki;Y. Sawama
中科院分区：
文献类型：
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作者：
Naoki Yasukawa;Marina Kuwata;T. Imai;Y. Monguchi;H. Sajiki;Y. Sawama
在非均相铜/碳（Cu/C）催化剂上，以3，6-二氢-1，2-恶嗪为原料，在纯加热条件下，可以有效地合成高官能化的吡咯。此外，通过亚硝基亲二烯体与1，3-二烯之间的杂Diels-Alder反应原位形成3，6-二氢-1，2-恶嗪以及随后的Cu/C催化的吡咯合成也以一锅法提供了相应的吡咯衍生物。
Highly-functionalized pyrroles could be effectively synthesized from 3,6-dihydro-1,2-oxazines using a heterogeneous copper on carbon (Cu/C) under neat heating conditions. Furthermore, the in situ formation of 3,6-dihydro-1,2-oxazines via the hetero Diels–Alder reaction between nitroso dienophiles and 1,3-dienes and the following Cu/C-catalyzed pyrrole synthesis also provided the corresponding pyrrole derivatives in a one-pot manner.