A family study of pathological gambling
A family study of pathological gambling
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DOI：
10.1016/j.psychres.2005.12.005
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发表时间：
2006-03-30
影响因子：
11.3
通讯作者：
Shaw, M
中科院分区：
文献类型：
--
作者：
Black, DW;Monahan, PO;Shaw, M
病态赌博（PG）的原因尚不清楚。目前的研究是为了确定PG是否是家族性的，并检查精神疾病的家族聚集模式。为此，招募了31例DSM-IV PG先证者和31例对照先证者，并就其一级亲属（FDR）进行了访谈。可用的和愿意FDR直接采访了已知的可靠性结构化工具，最佳估计的最终诊断盲分配193例和142例对照亲属年龄超过18岁。结果采用广义估计方程法进行Logistic回归分析。PG和“任何赌博障碍”的终生发生率在病例先证者亲属中（分别为8.3%和12.4%）显著高于对照亲属（分别为2.1%和3.5%）（“任何赌博障碍”的OR=3.36）。PG亲属的酒精障碍、“任何物质使用障碍”、反社会人格障碍（ASPD）和“任何精神障碍”的终生患病率也显著较高。“任何赌博障碍”、酒精障碍和“任何物质使用障碍”在保守的Bonferroni校正后仍然显著。有趣的是，PG家庭显着大于对照家庭。我们的结论是赌博障碍是家族性的，并与药物滥用共同聚集。数据还表明PG与ASPD共聚集。对PG的遗传力的进一步研究是必要的。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
The cause of pathological gambling (PG) is unknown. The current study was conducted to determine whether PG is familial, and to examine patterns of familial aggregation of psychiatric disorder. To that end, 31 case probands with DSM-IV PG and 31 control probands were recruited and interviewed regarding their first degree relatives (FDRs). Available and willing FDRs were directly interviewed with structured instruments of known reliability, and best estimate final diagnoses were blindly assigned for 193 case and 142 control relatives over age 18 years. The results were analyzed using logistic regression by the method of generalized estimating equations. The lifetime rates of PG and "any gambling disorder" were significantly greater among the relatives of case probands (8.3% and 12.4%, respectively) than among the control relatives (2.1% and 3.5%, respectively) (OR=3.36 for "any gambling disorder"). PG relatives also had significantly higher lifetime rates of alcohol disorders, "any substance use disorder," antisocial personality disorder (ASPD), and "any mental disorder". "Any gambling disorder," alcohol disorder, and "any substance use disorder" remained significant after a conservative Bonferroni correction. Interestingly, PG families were significantly larger than control families. We conclude that gambling disorders are familial and co-aggregate with substance misuse. The data are also suggestive that PG co-aggregates with ASPD. Further research on the heritability of PG is warranted. (c) 2005 Elsevier Ireland Ltd. All rights reserved.