Histopathologic evaluation of the internal limiting membrane surgically excised from eyes with diabetic maculopathy
Histopathologic evaluation of the internal limiting membrane surgically excised from eyes with diabetic maculopathy
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DOI：
10.1097/00006982-200504000-00010
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发表时间：
2005-04-01
影响因子：
3.3
通讯作者：
Ogura, Yuichiro
中科院分区：
文献类型：
--
作者：
Matsunaga, Noriko;Ozeki, Hironori;Ogura, Yuichiro
目的：组织病理学评价糖尿病黄斑水肿眼与非糖尿病对照眼的内界膜（ILM）。作者对5只糖尿病性黄斑病变眼的ILM标本进行了超微结构和免疫化学研究，其中4只患弥漫性糖尿病性黄斑水肿，1只患黄斑裂孔伴糖尿病性视网膜病变（DM组）和5例非糖尿病性特发性黄斑裂孔（MH组）。结果：糖尿病组玻璃体侧ILM细胞成分较多。DM组ILM厚度（平均4.8 ± 1.6 μ m）较MH组（1.8 ± 0.6 μ m）显著增加（P < 0.0001）。DM组内界膜中硫酸乙酰肝素蛋白聚糖的免疫反应比MH组丰富。结论：内界膜增厚和玻璃体表面细胞丰富可能与糖尿病性黄斑病变的病程和发病机制有关。
Purpose: To histopathologically evaluate the internal limiting membrane (ILM) in diabetic eyes with macular edema as compared to nondiabetic controls.Methods: The authors ultrastructurally and immunohistochemically studied ILM specimens that were intentionally peeled from five eyes with diabetic maculopathy, comprising four with diffuse diabetic macular edema and one with macular hole accompanying diabetic retinopathy (DM group), and five with nondiabetic idiopathic macular hole (MH group). They compared ultrastructural and immunohistochemical findings between the two groups.Results: A larger amount of cellular elements was observed on the vitreous side of the ILM in the DM group. The thickness of the ILM in the DM group was significantly increased (mean 4.8 +/- 1.6 mu m) compared with that in the MH group (1.8 +/- 0.6 mu m) (P < 0.0001). Immunoreactions for heparan sulfate proteoglycan in the ILM were more abundant in the DM group than in the MH group.Conclusion: The ILM thickening and cell abundance on the vitreous surface might contribute to the course and the pathogenesis of diabetic maculopathy.