Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants.
Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants.
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DOI：
10.1016/j.ccell.2022.09.006
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发表时间：
2022-09
期刊：
影响因子：
50.3
通讯作者：
Semanti Mukherjee;Jian Carrot-Zhang
中科院分区：
文献类型：
--
作者：
Semanti Mukherjee;Jian Carrot-Zhang
在这一期的《癌细胞》杂志中，Wang et al.使用全基因组测序的肺癌病例和对照与东亚血统，全面表征常见和罕见的变异，易患肺癌。他们的研究结果表明，BRCA2中罕见的启动子变异与肺癌风险增加有关。
In this issue ofCancer Cell, Wang et al. use whole-genome sequencing of lung cancer cases and controls with East Asian ancestry to comprehensively characterize both common and rare variants that predispose to lung cancer. Their findings suggest that rare promoter variants inBRCA2are associated with increased lung cancer risk.