Single Virus Detection on Silicon Photonic Crystal Random Cavities.
Single Virus Detection on Silicon Photonic Crystal Random Cavities.
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DOI：
10.1002/smll.202107597
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发表时间：
2022-02
期刊：
影响因子：
13.3
通讯作者：
Keisuke Watanabe;Hsin-Yu Wu;J. Xavier;L. T. Joshi;F. Vollmer
中科院分区：
文献类型：
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作者：
Keisuke Watanabe;Hsin-Yu Wu;J. Xavier;L. T. Joshi;F. Vollmer
芯片上的硅微腔传感器由于其紧凑性和与分析物的增强的光-物质相互作用而有利于检测病毒和生物分子。虽然它们的理论灵敏度处于单分子水平，但高质量（Q）因子硅腔的制造及其与光耦合器的集成仍然是诸如单病毒检测等应用中的主要障碍。在这里，提出并证明了使用硅光子晶体随机腔的无标记单病毒检测。传感器芯片由独立的硅光子晶体波导组成，不需要预制的缺陷腔或光耦合器。剩余的制造无序导致安德森局域腔模，其由自由空间光束激发。Q λ 105足以观察单个腺病毒结合的共振波长的离散阶跃变化（半径约50 nm）。作者的研究结果指出了CMOS兼容硅传感器芯片的未来应用，这些芯片支持安德森局域模式，具有单个纳米颗粒和分子水平的检测能力。
On-chip silicon microcavity sensors are advantageous for the detection of virus and biomolecules due to their compactness and the enhanced light-matter interaction with the analyte. While their theoretical sensitivity is at the single-molecule level, the fabrication of high quality (Q) factor silicon cavities and their integration with optical couplers remain as major hurdles in applications such as single virus detection. Here, label-free single virus detection using silicon photonic crystal random cavities is proposed and demonstrated. The sensor chips consist of free-standing silicon photonic crystal waveguides and do not require pre-fabricated defect cavities or optical couplers. Residual fabrication disorder results in Anderson-localized cavity modes which are excited by a free space beam. The Q ≈105 is sufficient for observing discrete step-changes in resonance wavelength for the binding of single adenoviruses (≈50 nm radius). The authors' findings point to future applications of CMOS-compatible silicon sensor chips supporting Anderson-localized modes that have detection capabilities at the level of single nanoparticles and molecules.