Catch-up growth: possible mechanisms
Catch-up growth: possible mechanisms
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DOI：
10.1007/s004670000338
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发表时间：
2000-07-01
影响因子：
3
通讯作者：
Baron, J
中科院分区：
文献类型：
--
作者：
Gafni, RI;Baron, J
许多全身性疾病损害了线性生长。如果出现缓解，生长速度通常会超过正常年龄，这一现象被称为“追赶生长”。因此，最终的身高得到了改善，尽管这种成年人身高的恢复往往是不完整的。为了解释追赶式增长，人们提出了两个主要模型。第一个模型假设了一种中枢神经系统机制，该机制将实际身体尺寸与年龄合适的设定点进行比较，然后相应地调整生长速度。然而，最近有证据表明，单个生长板中的生长抑制之后是局部追赶生长，这一发现不容易用神经内分泌模型解释。因此，已经提出了一种新的模型，将该机制置于生长板本身。根据这一模型，生长抑制条件减少了生长板干细胞的增殖，从而保存了它们的增殖能力。还需要进一步的研究，以确定管理追赶增长的机制是局部的、系统性的，还是两者兼而有之。
Many systemic diseases impair linear growth. If remission occurs, growth will often accelerate beyond the normal rate for age, a phenomenon termed "catch-up growth." As a result, final height is improved, although this recovery of adult stature is frequently incomplete. Two principal models have been proposed to explain catch-up growth. The first model postulates a central nervous system mechanism that compares actual body size with an age-appropriate set-point and then adjusts growth rate accordingly. However, there is recent evidence that growth inhibition in a single growth plate is followed by local catch-up growth, a finding not readily explained by the neuroendocrine model. Thus, a new model has been proposed that places the mechanism within the growth plate itself. According to this model, growth-inhibiting conditions decrease proliferation of growth plate stem cells, thus conserving their proliferative potential. Additional research is needed to determine whether the mechanisms governing catch-up growth are local, systemic, or both.