Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study
Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease: A Longitudinal MRI Study
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DOI：
10.3174/ajnr.a6021
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发表时间：
2019-05-01
影响因子：
3.5
通讯作者：
Benders, M. J. N. L.
中科院分区：
文献类型：
--
作者：
Claessens, N. H. P.;Khalili, N.;Benders, M. J. N. L.
背景和目的：患有严重先天性心脏病的胎儿和新生儿面临大脑发育迟缓和神经发育障碍的风险。我们的目的是在产前诊断为危重先天性心脏病的纵向扫描队列中调查胎儿和新生儿脑容量与新生儿脑损伤之间的关联，并将胎儿和新生儿脑容量与经后年龄和先天性心脏病类型联系起来。 材料和方法：这是一项前瞻性纵向研究，包括 61 名接受体外循环手术的危重先天性心脏病新生儿。
BACKGROUND AND PURPOSE: Fetuses and neonates with critical congenital heart disease are at risk of delayed brain development and neurodevelopmental impairments. Our aim was to investigate the association between fetal and neonatal brain volumes and neonatal brain injury in a longitudinally scanned cohort with an antenatal diagnosis of critical congenital heart disease and to relate fetal and neonatal brain volumes to postmenstrual age and type of congenital heart disease.MATERIALS AND METHODS: This was a prospective, longitudinal study including 61 neonates with critical congenital heart disease undergoing surgery with cardiopulmonary bypass