The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
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DOI：
10.1016/s0166-4328(96)89080-2
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发表时间：
1996-11-01
影响因子：
2.7
通讯作者：
Neave, N
中科院分区：
文献类型：
--
作者：
Aggleton, JP;Hunt, PR;Neave, N
各组大鼠接受以丘脑前内侧核(AM)、丘脑前腹侧核(AV/AD)和丘脑前背侧核(AV/AD)为中心的细胞毒性损伤，或所有三个核的联合损伤(ANT.T)。采用N-甲基-D-天冬氨酸(NMDA)注射法制作损伤模型。这些大鼠和一组手术对照组(Sham)在T型迷宫中接受了一项有奖励的强迫交替任务的训练。虽然选择性AM和AV/AD损害产生了最初的获得性损害，但只有合并损害的动物(ANT.T)在16次获得过程中显示出持续的缺陷。随后的交叉迷宫测试证实，Sham组、AV/AD组和AM组能够使用异地着丝点线索，而ANT.T组则受到损害。相比之下，在随后的自我中心辨别和反转任务中，三组丘脑前部的受试者都没有受到影响。最后一次使用八臂径向迷宫的测试显示，ANT.T组有明显的缺陷，而AV/AD组的缺陷较轻。这些实验的结果有助于确认丘脑前核团对分配中心任务的重要性，但也表明没有哪个区域是最重要的。这一发现也有助于解释其他研究，这些研究报告称，丘脑前部损伤对空间记忆测试的影响似乎很轻微。
Groups of rats received cytotoxic lesions centred in either the anterior medial thalamic nucleus (AM), the anterior ventral and anterior dorsal thalamic nuclei (AV/AD), or all three nuclei combined (ANT.T). These lesions were made by injecting N-methyl-D-aspartate acid (NMDA). These rats, and a group of surgical controls (SHAM), were trained on a rewarded forced-alternation task in a T-maze. While the selective AM and AV/AD lesions produced an initial acquisition impairment, only the animals with combined lesions (ANT.T) showed a persistent deficit throughout the 16 acquisition sessions. Subsequent testing with a cross-maze confirmed that the SHAM, AV/AD, and AM groups were able to use allocentric cues, while the ANT.T group were impaired. In contrast none of the three anterior thalamic groups were impaired on a subsequent egocentric discrimination and reversal task run in the same apparatus. A final test using the eight arm radial-maze, revealed marked deficits in the ANT.T group as well as milder deficits in the AV/AD group. The results from these experiments help to confirm the importance of the anterior thalamic nuclei for allocentric tasks, but suggest that no region is pre-eminently important. The findings also help to account for other studies which have reported that anterior thalamic lesions have seemingly mild effects on tests of spatial memory.