A case report of anti-N-methyl-d-aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6.
A case report of anti-N-methyl-d-aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6.
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染色体整合型人疱疹病毒6型抗N-甲基-D-天冬氨酸受体脑炎一例报告。
DOI：
10.1111/ncn3.12681
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Isobe N.
中科院分区：
文献类型：
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作者：
Iwao K;Watanabe M;Mukaino T;Fujii T;Yamasaki R;Isobe N.
染色体整合的人类疱疹病毒6型（CiHHV 6）是HHV 6-DNA整合到宿主生殖系基因组中的一种情况。ciHHV 6可被误诊为活动性HHV 6感染。我们报告一名30岁的女性，表现为心理症状，无免疫缺陷病史。她患有卵巢畸胎瘤，脑脊液（CSF）中存在抗-N-甲基-D-天冬氨酸受体（NMDAR）抗体，血清和CSF中存在HHV 6-DNA。最终诊断为抗NMDAR脑炎和ciHHV 6，因为腹腔镜卵巢切除术和免疫治疗改善了她的症状，并且在她的口腔粘膜细胞中检测到HHV 6-DNA。该病例表明，当在脑炎患者的CSF中检测到HHV 6-DNA时，需要评估HHV 6-DNA是否与感染或ciHHV 6相关。
Chromosomally integrated human herpesvirus 6 (ciHHV6) is a condition where HHV6‐DNA is integrated into the host germline genome. ciHHV6 can be misdiagnosed as active HHV6 infection. We report a 30‐year‐old woman presenting with psychological symptoms without a history of immunodeficiency. She had an ovarian teratoma and anti‐N‐methyl‐D‐aspartate receptor (NMDAR) antibodies in the cerebrospinal fluid (CSF) with HHV6‐DNA in the serum and CSF. The final diagnosis was anti‐NMDAR encephalitis and ciHHV6 because laparoscopic oophorectomy and immunotherapy ameliorated her symptoms and HHV6‐DNA was detected in her oral mucosa cells. This case suggests the need to assess whether HHV6‐DNA is related to infection or ciHHV6 when HHV6‐DNA is detected in the CSF of patients with encephalitis.