Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.
Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.
复制标题
新型喹啉磺酰胺调节人乳腺细胞对紫杉醇的敏感性。
DOI：
10.1016/s0960-894x(01)00462-0
复制
发表时间：
2001
影响因子：
2.7
通讯作者：
Bernacki,RJ
中科院分区：
文献类型：
--
作者：
Chibale,K;Ojima,I;Haupt,H;Geng,X;Pera,P;Bernacki,RJ
Sulfonamide derivatives of chloroquine and primaquine were synthesised and evaluated against both paclitaxel-sensitive and paclitaxel-resistant mammarian cancer cell lines. All derivatives exhibited at least 96% MDR reversal activity when co-administered with paclitaxel at 5 μM. The best compound, a chloroquine derivative, exhibited 99% MDR reversal activity when co-administered with paclitaxel at 1 μM. Molecular modelling studies reveal that these derivatives share a common pharmacophore with taxane MDR reversal agents.
