The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase.
The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase.
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DOI：
10.1159/000073790
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发表时间：
2003
影响因子：
--
通讯作者：
J. Kang
中科院分区：
文献类型：
--
作者：
J. Kang
本文提供了在分子水平上omega-6/ omega-3脂肪酸比例的重要性的科学证据。在这项研究中，在培养的心肌细胞和癌细胞中插入缺失的δ-3去饱和酶，导致从18：2ω6产生18：3ω3，并从花生四烯酸形成二十碳五烯酸。这个过程一直持续到omega-6和omega-3之间的比例达到1：1。这些结果表明，低的或平衡的ω-6/ω-3脂肪酸比率在不同的细胞类型中发挥有益的作用（即，降低心脏细胞对心律失常的敏感性，增加癌细胞的凋亡）。
This paper presents scientific evidence on the importance of the omega-6/ omega-3 fatty acid ratio at the molecular level. In the study, insertion of a missing delta-3 desaturase in cardiac myocytes and cancer cells in culture led to the production of 18:3ω3 from 18:2ω6, and in the formation of eicosapentaenoic acid from arachidonic acid. This process proceeded until the ratio between omegea-6 and omega-3 reached 1:1. These results suggest that a low or balanced omega-6/omega-3 fatty acid ratio exerts a beneficial effect in different cell types (i.e., decreased susceptibility of heart cells to arrhythmia, increased apoptosis of cancer cells).