Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa
Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa
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来自草酸青霉 EN-201 的两种新生物碱，一种源自海洋红树林植物红树的内生真菌
DOI：
10.1016/j.phytol.2015.06.009
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发表时间：
2015-09-01
影响因子：
1.7
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Zhang, Peng;Li, Xiao-Ming;Wang, Bin-Gui
从海洋红树林植物红海榄（Rhizophora stylosa）鲜叶内生真菌Penicillium peculicum EN-201中分离并鉴定了两个新生物碱，包括一个新的异戊烯化吲哚衍生物penioxamide A（1）和一个新的decaturin类似物18-hydroxydecaturin B（2）。根据光谱数据和圆二色谱分析，确定了它们的结构和绝对构型。化合物1在双环[2.2.2]二氮杂辛烷环上具有罕见的反相对构型，而化合物2具有在天然产物中罕见的吡啶基-a-吡喃酮亚结构。化合物1和2显示出有效的卤虫致死性，LD 50值分别为5.6和2.3 μ M。(C)2015年欧洲植物化学学会。Elsevier B. V.出版，保留所有权利。
Two new alkaloids including a new prenylated indole derivative possessing a piperidine moiety, penioxamide A (1), and a new decaturin analogue, 18-hydroxydecaturin B (2), were isolated and identified from Penicillium oxalicum EN-201, an endophytic fungus obtained from the inner tissue of the fresh leaves of marine mangrove plant Rhizophora stylosa. Their structures and absolute configurations were elucidated on the basis of the spectral data and CD analysis. Compound 1 bears the rare anti relative configuration in the bicyclo[2.2.2]diazaoctane ring, while compound 2 has a pyridinyl-a-pyrone substructure which is rare among natural products. Compounds 1 and 2 showed potent brine shrimp lethality with LD50 values of 5.6 and 2.3 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.