Avian and Mammalian Facilitative Glucose Transporters.
Avian and Mammalian Facilitative Glucose Transporters.
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DOI：
10.3390/microarrays6020007
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发表时间：
2017-04-05
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Byers MS;Howard C;Wang X
GLUT成员属于促进葡萄糖跨细胞膜转运的葡萄糖转运蛋白家族。哺乳动物GLUT家族由13个成员（GLUT 1-12和H+-肌醇转运蛋白（HMIT））组成。人类有一个最近复制的GLUT成员，GLUT 14。鸟类表达了GLUT成员的大多数。多种GLUT在所有体细胞组织中的排列表明葡萄糖在所有生物体中的重要作用。葡萄糖转运缺陷与代谢紊乱、胰岛素抵抗和糖尿病有关。尽管这些转运蛋白至关重要，但我们对鸟类GLUT成员的了解是分散的。很明显，没有哺乳动物GLUT 4和GLUT 7的鸡直系同源物。我们对鸡中GLUT成员的研究表明，一些鸡GLUT成员在哺乳动物中没有相应的直系同源物。我们回顾了有关GLUT同源基因及其在哺乳动物和鸟类中的功能和表达的信息，重点是鸡和人类。
The GLUT members belong to a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. The mammalian GLUT family consists of thirteen members (GLUTs 1–12 and H+-myo-inositol transporter (HMIT)). Humans have a recently duplicated GLUT member, GLUT14. Avians express the majority of GLUT members. The arrangement of multiple GLUTs across all somatic tissues signifies the important role of glucose across all organisms. Defects in glucose transport have been linked to metabolic disorders, insulin resistance and diabetes. Despite the essential importance of these transporters, our knowledge regarding GLUT members in avians is fragmented. It is clear that there are no chicken orthologs of mammalian GLUT4 and GLUT7. Our examination of GLUT members in the chicken revealed that some chicken GLUT members do not have corresponding orthologs in mammals. We review the information regarding GLUT orthologs and their function and expression in mammals and birds, with emphasis on chickens and humans.