Hidden epidemic of macrolide-resistant pneumococci.

Hidden epidemic of macrolide-resistant pneumococci.
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DOI:
10.3201/eid1106.050147
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发表时间:
2005-06
影响因子:
11.8
通讯作者:
Lonks JR
Lonks JR
中科院分区:
医学2区
文献类型:
--
作者:
Klugman KP;Lonks JR

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社区获得性呼吸道感染(RTI)占全世界门诊抗菌药物处方的很大比例。对肺炎球菌出现多重耐药的关注主要集中在耐青霉素肺炎链球菌上。大环内酯类抗菌药物已被广泛用于经验性治疗社区获得性呼吸道感染,因为它们对常见和非典型呼吸道病原体,包括肺炎链球菌都有疗效。然而,大环内酯类药物使用量的增加与肺炎球菌耐药性的全球增加有关,这导致了人们对大环内酯类药物治疗社区获得性呼吸道感染的持续临床疗效的担忧。我们提供了对大环内酯类耐药肺炎链球菌的概述,并评估了这种耐药性对社区获得性呼吸道感染经验性治疗的影响。
Community-acquired respiratory tract infections (RTIs) account for a substantial proportion of outpatient antimicrobial drug prescriptions worldwide. Concern over the emergence of multidrug resistance in pneumococci has largely been focused on penicillin-resistant Streptococcus pneumoniae. Macrolide antimicrobial drugs have been widely used to empirically treat community-acquired RTIs because of their efficacy in treating both common and atypical respiratory pathogens, including S. pneumoniae. However, increased macrolide use has been associated with a global increase in pneumococcal resistance, which is leading to concern over the continued clinical efficacy of the macrolides to treat community-acquired RTIs. We provide an overview of macrolide-resistant S. pneumoniae and assess the impact of this resistance on the empiric treatment of community-acquired RTIs.
DOI: 10.1128/aac.44.1.43-50.2000
发表时间: 2000-01-01
影响因子: 4.9
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