Principles of Saliva Secretion
Principles of Saliva Secretion
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DOI：
10.1111/j.1749-6632.1993.tb18338.x
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发表时间：
1993-09
影响因子：
5.2
通讯作者：
Bruce J. Baum
中科院分区：
文献类型：
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作者：
Bruce J. Baum
唾液腺由高度分化的上皮细胞组成，能够分泌大量的液体和外分泌蛋白，具有相当特殊的口腔内功能。这些腺体由两个不同的功能和解剖区域组成，腺泡和导管(图1)。腺泡区或分泌末端通常由一种或(至多)两种细胞类型组成。它是(I)所有液体产生和(Ii)腺体大部分(-85%)外分泌蛋白质分泌的地方。液体成分来自局部血管床，以等渗(即-140mequiv/L NaCI)的形式“初级”分泌到腺泡管腔。这种初级液体通过管道系统(4-5种不同的细胞类型)进入口腔。在这一点上，需要强调的是腺泡细胞是透水的，而导管细胞是不透水的。当形成的唾液穿过导管区域时，会产生相当大的电解质通量。大部分Na+和Cl-被重吸收，少量K+和HCO被分泌。此外，还添加了一些蛋白质。当最后的唾液进入口腔时，它已明显处于低渗状态(-25mequivb
Salivary glands are composed of highly differentiated epithelial cells and are capable of secreting copious amounts of fluid and exocrine proteins with quite specialized intraoral functions. These glands consist of two distinct functional and anatomic regions, acinar and ductal (FIGURE 1). The acinar region, or secretory endpiece, typically consists of one or (at most) two cell types. It is the site of (i) all fluid generation and (ii) most (-85%) exocrine protein secretion in the gland.’The fluid component is derived from the local vascular bed in the form of an isotonic (ie,-140 mequiv/L NaCI)“primary” secretion into the acinar lumen. This primary fluid is carried via the duct system (4-5 distinct cell types) into the mouth. In this regard, it is important to emphasize that acinar cells are water-permeable, whereas ductal cells are water-impermeable. As the forming saliva traverses the ductal region, considerable electrolyte flux occurs. Most Na+ and C1-are reabsorbed and a small amount of K+ and HCO; are secreted. Furthermore, some proteins are added as well. By the time the final saliva enters the mouth, it is markedly hypotonic (-25 mequivb