Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans
Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans
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DOI：
10.1038/npp.2015.53
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发表时间：
2015-08-01
影响因子：
7.6
通讯作者：
D'Souza, Deepak Cyril
中科院分区：
文献类型：
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作者：
Cortes-Briones, Jose;Skosnik, Patrick D.;D'Souza, Deepak Cyril
伽马（gamma）波段振荡在感知、联想学习和意识意识中起着关键作用，并且在动物研究中被大麻素破坏。本研究的目的是确定大麻素是否会破坏人类的γ振荡，以及这些影响是否与精神病相关的行为影响有关。在人（n=20）中研究了Delta-9-四氢大麻酚（Delta（9）-THC）对听觉稳态反应（ASSR）的急性、剂量相关作用，这些人完成了3个测试日，在此期间，他们以双盲、随机、交叉和平衡设计接受静脉内Delta（9）-THC（安慰剂，0.015和0.03 mg/kg）。当受试者听到以20、30和40 Hz呈现的听觉点击串时，记录脑电图（EEG）。用阳性和阴性症状量表（PANSS）测量精神病相关效应。与0.015 mg/kg和安慰剂相比，Delta（9）-THC（0.03 mg/kg）降低了40 Hz条件下的三重相干（ITC）。30和20 Hz刺激未检测到显著影响。此外，在Delta（9）-THC的影响下，40 Hz ITC和PANSS分量表与总分呈负相关。Delta（9）-THC（0.03 mg/kg）在40 Hz刺激期间以趋势水平降低诱发功率。最近吸食大麻的人显示Delta（9）-THC对ITC和诱发功率的影响减弱。我们首次在人类身上证明大麻素会破坏伽马波段神经振荡。此外，伽马波段神经振荡的中断与大麻素诱导的精神病相关现象之间存在关系。这些发现增加了越来越多的文献，表明大麻素的急性作用与精神障碍中观察到的行为和心理生理学改变之间存在一些重叠。
Gamma (gamma)-band oscillations play a key role in perception, associative learning, and conscious awareness and have been shown to be disrupted by cannabinoids in animal studies. The goal of this study was to determine whether cannabinoids disrupt gamma-oscillations in humans and whether these effects relate to their psychosis-relevant behavioral effects. The acute, dose-related effects of Delta-9-tetrahydrocannabinol (Delta(9)-THC) on the auditory steady-state response (ASSR) were studied in humans (n=20) who completed 3 test days during which they received intravenous Delta(9)-THC (placebo, 0.015, and 0.03 mg/kg) in a double-blind, randomized, crossover, and counterbalanced design. Electroencephalography (EEG) was recorded while subjects listened to auditory click trains presented at 20, 30, and 40 Hz. Psychosis-relevant effects were measured with the Positive and Negative Syndrome scale (PANSS). Delta(9)-THC (0.03 mg/kg) reduced intertrialcoherence (ITC) in the 40 Hz condition compared with 0.015 mg/kg and placebo. No significant effects were detected for 30 and 20 Hz stimulation. Furthermore, there was a negative correlation between 40 Hz ITC and PANSS subscales and total scores under the influence of Delta(9)-THC. Delta(9)-THC (0.03 mg/kg) reduced evoked power during 40 Hz stimulation at a trend level. Recent users of cannabis showed blunted Delta(9)-THC effects on ITC and evoked power. We show for the first time in humans that cannabinoids disrupt gamma-band neural oscillations. Furthermore, there is a relationship between disruption of gamma-band neural oscillations and psychosis-relevant phenomena induced by cannabinoids. These findings add to a growing literature suggesting some overlap between the acute effects of cannabinoids and the behavioral and psychophysiological alterations observed in psychotic disorders.