Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection
Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection
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应激颗粒的形成是宿主细胞对抗柯萨奇病毒 B 感染的早期抗病毒机制之一
DOI：
10.1007/s12250-018-0040-3
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发表时间：
2018-06
影响因子：
5.5
通讯作者：
Zhaohua Zhong
中科院分区：
文献类型：
--
作者：
Xia Zhai;Shuo Wu;Lexun Lin;Tianying Wang;Xiaoyan Zhong;Yang Chen;Weizhen Xu;Lei Tong;Yan Wang;Wenran Zhao;Zhaohua Zhong
应激颗粒（Stress granules，SG）是细胞翻译受阻时形成的细胞内颗粒，已被报道与多种病毒感染有关。我们的前期研究表明，SGs参与了柯萨奇病毒B（CVB）的感染过程，但SGs在CVB感染中的作用尚未完全阐明。在本研究中，我们发现CVB 3型（CVB 3）可以在感染早期诱导SG形成。结果表明，在CVB3感染的早期阶段，通过增加SG的形成，CVB3 RNA和蛋白质的水平显著受到抑制，而当SG形成被阻断时，病毒RNA和蛋白质的合成显著受到促进。我们的研究结果表明，SG形成是宿主细胞抗CVB感染的早期抗病毒机制之一。
Stress granules (SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B (CVB) infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3 (CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.
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