Ascending SAG Neurons Control Sexual Receptivity of Drosophila Females
Ascending SAG Neurons Control Sexual Receptivity of Drosophila Females
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DOI：
10.1016/j.neuron.2014.05.017
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发表时间：
2014-07-02
期刊：
影响因子：
16.2
通讯作者：
Dickson, Barry J.
中科院分区：
文献类型：
--
作者：
Feng, Kai;Palfreyman, Mark T.;Dickson, Barry J.
交配会引起雌性生殖行为的明显变化，通常包括性接受能力的急剧下降。在果蝇中，交配后的行为变化是由性肽（SP）触发的，性肽是一种雄性精液肽，通过雌性生殖道感觉神经元（SPSN）中表达的受体（SPR）起作用。在这里，我们确定二阶神经元介导的SP诱导的行为变化。这些SAG神经元接收来自SPSNs在腹神经节的突触输入和项目的背侧前脑。沉默SAG神经元使处女女性不接受，而激活它们增加了已经交配的女性的接受性。生理实验表明，SP下调SPSNs的兴奋性，因此他们的输入到SAG神经元。因此，这些数据提供了雌性中枢神经系统中交配状态的生理相关性，以及控制性感受性的大脑回路的关键入口点。
Mating induces pronounced changes in female reproductive behavior, typically including a dramatic reduction in sexual receptivity. In Drosophila, post-mating behavioral changes are triggered by sex peptide (SP), a male seminal fluid peptide that acts via a receptor (SPR) expressed in sensory neurons (SPSNs) of the female reproductive tract. Here, we identify second-order neurons that mediate the behavioral changes induced by SP. These SAG neurons receive synaptic input from SPSNs in the abdominal ganglion and project to the dorsal protocerebrum. Silencing SAG neurons renders virgin females unreceptive, whereas activating them increases the receptivity of females that have already mated. Physiological experiments demonstrate that SP down-regulates the excitability of the SPSNs, and hence their input onto SAG neurons. These data thus provide a physiological correlate of mating status in the female central nervous system and a key entry point into the brain circuits that control sexual receptivity.