Effect of natural grass pollen exposure on exhaled nitric oxide in asthmatic children
Effect of natural grass pollen exposure on exhaled nitric oxide in asthmatic children
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DOI：
10.1164/ajrccm.159.1.9804063
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发表时间：
1999-01-01
影响因子：
24.7
通讯作者：
Zacchello, F
中科院分区：
文献类型：
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作者：
Baraldi, E;Carrà, S;Zacchello, F
哮喘患者呼出气中一氧化氮（NO）含量增加。本研究的目的是探讨花粉过敏性哮喘儿童在室外和花粉季节呼出气NO的纵向变化。21名儿童（年龄6至16岁），季节性过敏性哮喘敏感草花粉，进行了测量呼出NO和肺功能之前（3月），期间（5月），后（11月）花粉季节。采用化学发光分析仪测定潮气呼吸法呼出的NO，并记录NO稳态水平。在花粉季节的测量时间是基于大气花粉计数。将哮喘儿童呼出气NO值与21名性别和年龄匹配的健康儿童进行比较。每次访视时还评估了肺功能和哮喘症状。草季前呼出的NO的平均值为12.7 +/- 5.1 ppb（平均值+/- SD），与对照组（7.8 +/- 2.7 ppb，p < 0.001）相比显著更高。在花粉季节，呼出的NO（21.4 +/- 7.6 ppb）显著增加（p < 0.001）两倍，在花粉季节之后，返回到与花粉季节之前发现的值相似的值（12.8 +/- 5.8 ppb，p = NS）。FEV 1在赛季前和赛季中没有显著变化（98.6%预测值vs 101%预测值，p = NS）。我们的结论是，天然过敏原暴露与哮喘草花粉过敏的儿童呼出的NO增加，即使在没有显着变化的气道功能。我们推测，呼出的NO的测量可能是一个敏感的非侵入性哮喘疾病活动的标志物。
Exhaled nitiric oxide (NO) is increased in exhaled breath of asthmatic patients. The aim of this study was to investigate the longitudinal changes of exhaled NO outside and during the pollen season in pollen-allergic asthmatic children. Twenty-one children (age 6 to 16 yr), with a seasonal allergic asthma sensitive to grass pollen, underwent measurements of exhaled NO and pulmonary function before (March), during (May), and after (November) the pollen season. Exhaled NO was measured by a tidal breathing method with a chemiluminescence analyzer and NO steady-state levels were recorded. The timing of the measurements during the pollen season was based on the atmospheric pollen count. Exhaled NO values of asthmatic children were compared with those of 21 sex- and age-matched healthy children. Pulmonary function and symptoms of asthma were also evaluated at each visit. The mean value of exhaled NO before the grass season was 12.7 +/- 5.1 ppb (mean +/- SD), significantly higher when compared with controls (7.8 +/- 2.7 ppb, p < 0.001). In the pollen season there was a significant (p < 0.001) twofold increase in exhaled NO (21.4 +/- 7.6 ppb) that, after the season, returned to values similar (12.8 +/- 5.8 ppb, p = NS) to those found before the season. There were no significant changes in FEV1 before and during the season (98.6% predicted versus 101% predicted, p = NS). We conclude that natural allergen exposure is related to an increase of exhaled NO in asthmatic grass pollen-allergic children even in absence of significant changes in airways function. We speculate that measurement of exhaled NO could be a sensitive noninvasive marker of asthma disease activity.