Complement and natural antibody are required in the long-term memory response to influenza virus
Complement and natural antibody are required in the long-term memory response to influenza virus
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DOI：
10.1016/j.vaccine.2008.11.057
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发表时间：
2008-12-30
期刊：
影响因子：
5.5
通讯作者：
Carroll, Michael C.
中科院分区：
文献类型：
--
作者：
Gonzalez, Santiago Fernandez;Jayasekera, Jerome Priyantha;Carroll, Michael C.
补体、补体受体和天然抗体（IgM）是针对病原体的免疫反应的重要因素。先前的研究表明 C3、补体受体 CD35/CD21 (CR1/CR2) 和 IgM 在流感病毒的免疫反应中发挥作用。然而，它们对这种病原体的长期记忆反应的贡献仍然未知。为了阐明这一作用，我们描述了缺乏 CR1/CR2 (Cr2-/-)、C3 (C3-/-)、分泌型 IgM (mu s-/-) 和双敲除 C3-/-mu s-/- 的小鼠的继发反应。总的来说，我们的结果表明，C3、IgM 和 CR1/CR2 在流感病毒长期记忆的维持中发挥着至关重要的作用，可能是通过记忆 B 细胞的发育和长期抗体分泌来实现的。 (C) 2008 Elsevier Ltd. 保留所有权利。
Complement, complement receptors and natural antibody (IgM) are important factors in the immune response against pathogens. Previous studies have indicated a role for C3, the complement receptors CD35/CD21 (CR1/CR2), and IgM in the immune response to influenza virus. Nevertheless, their contribution to the long-term memory response to this pathogen remains unknown. To elucidate this role, we characterized the secondary response on mice deficient of CR1/CR2 (Cr2-/-), C3 (C3-/-), secreted IgM (mu s-/-) and the double knockout C3-/-mu s-/-. Overall, our results suggest that C3, IgM and CR1/CR2 play crucial roles in the maintenance of long-term memory to influenza virus, possibly through the development of memory B cells and long-term antibody secretion. (C) 2008 Elsevier Ltd. All rights reserved.