Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development
复制标题
种系发育过程中，多个印记位点的非等位基因转移由 H19 印记控制区组织
DOI：
10.1101/gad.552109
复制
发表时间：
2009-11-15
影响因子：
10.5
通讯作者：
Ohlsson, Rolf
中科院分区：
文献类型：
--
作者：
Sandhu, Kuljeet Singh;Shi, Chengxi;Ohlsson, Rolf
最近的观察强调，哺乳动物基因组通过长程染色质相互作用广泛地与其自身通讯。然而，人们对这种染色质串扰与表观遗传状态之间的因果关系知之甚少。我们在这里确定了整个基因组中物理并置区域的网络，其共同点是基因组印记。此外，H19印记控制区（ICR）内的CTCF结合位点不仅决定了印记结构域之间的物理接近性，而且还将通过复制计时模式识别的等位基因特异性表观遗传状态转移到种系发育过程中相互作用的非等位基因印记区域。我们得出的结论是，一个基因座可以直接或间接地多效性地影响与其相互作用的其他染色体上多个区域的表观遗传状态。
Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.