Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes.
Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes.
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鉴定可激活静息 T 淋巴细胞的 T 辅助细胞衍生淋巴因子。
DOI：
10.1126/science.2935936
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Reinherz,EL
中科院分区：
文献类型：
--
作者：
Milanese,C;Richardson,NE;Reinherz,EL
在T细胞抗原- mhc（主要组织相容性复合体）受体（T3-Ti）交联后数小时内，辅助T细胞克隆会分泌一种分子大小为10至12千道尔的新型淋巴因子。这种被称为白细胞介素- 4a （IL-4A）的淋巴因子，通过结合可选T11途径的一个或多个表面组分，随后通过诱导白细胞介素-2 （IL-2）受体刺激静息淋巴细胞。激活过程既不依赖于募集群体的抗原特异性，也不依赖于巨噬细胞的存在。因此，IL-4A似乎是一种参与扩增T细胞免疫应答的介质。
A novel lymphokine with apparent molecular size of 10 to 12 kilodaltons is secreted from helper T cell clones within hours after cross-linking their T cell antigen-MHC (major histocompatibility complex) receptors (T3-Ti). This lymphokine, termed interleukin-4A (IL-4A), stimulates resting lymphocytes by binding to a surface component (or components) of the alternative T11 pathway and subsequently by inducing interleukin-2 (IL-2) receptors. The activation process is neither dependent on antigen specificities of the recruited population or the presence of macrophages. It appears, therefore, that IL-4A is a mediator involved in amplifying the T cell immune response.