The cognitive control network: Integrated cortical regions with dissociable functions
The cognitive control network: Integrated cortical regions with dissociable functions
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DOI：
10.1016/j.neuroimage.2007.03.071
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发表时间：
2007-08-01
期刊：
影响因子：
5.7
通讯作者：
Schneider, Walter
中科院分区：
文献类型：
--
作者：
Cole, Michael W.;Schneider, Walter
数百项已发表的研究一致表明，相同的皮层区域参与了多种形式的认知控制。利用功能磁共振成像（fMRI），我们发现这些共同活动的区域形成了一个功能连接的认知控制网络（CCN）。网络状态确定收敛的方法，包括：高区域间的相关性，在休息和任务的性能，一贯较高的相关性内的CCN比其余的皮层，共同激活的视觉搜索任务，和决策困难的相互敏感性。CCN内的区域包括前扣带皮层/前辅助运动区（ACC/ pSMA）、背外侧前额叶皮层（DLPFC）、下额叶连接（IFJ）、前岛叶皮层（AIC）、背侧前运动皮层（dPMC）和后顶叶皮层（PPC）。我们使用了一种新的视线搜索任务，其中包括期间，当探头刺激被遮挡，但受试者必须保持和更新工作记忆，准备突然出现的探头刺激。六个CCN区域在该任务的“非遮挡”部分期间作为紧密耦合的网络运行，所有区域都对探测事件做出响应。相比之下，网络在遮挡搜索期间被区分。当探针不存在时，DLPFC而不是ACC/pSMA参与目标记忆维持，而在每个闭塞期结束时，这两个区域都变得活跃，为困难的探针做准备。这种方法说明了一种方法，其中可以识别神经元网络，建立其高功能连接，并分离其组件，以更好地理解该网络的交互式和专门的内部机制。(C)2007爱思唯尔公司All rights reserved.
Consensus across hundreds of published studies indicates that the same cortical regions are involved in many forms of cognitive control. Using functional magnetic resonance imaging (fMRI), we found that these coactive regions form a functionally connected cognitive control network (CCN). Network status was identified by convergent methods, including: high inter-regional correlations during rest and task performance, consistently higher correlations within the CCN than the rest of cortex, co-activation in a visual search task, and mutual sensitivity to decision difficulty. Regions within the CCN include anterior cingulate cortex/pre- supplementary motor area (ACC/ pSMA), dorsolateral prefrontal cortex (DLPFC), inferior frontal junction (IFJ), anterior insular cortex (AIC), dorsal pre-motor cortex (dPMC), and posterior parietal cortex (PPC). We used a novel visual line search task which included periods when the probe stimuli were occluded but subjects had to maintain and update working memory in preparation for the sudden appearance of a probe stimulus. The six CCN regions operated as a tightly coupled network during the 'nonoccluded' portions of this task, with all regions responding to probe events. In contrast, the network was differentiated during occluded search. DLPFC, not ACC/pSMA, was involved in target memory maintenance when probes were absent, while both regions became active in preparation for difficult probes at the end of each occluded period. This approach illustrates one way in which a neuronal network can be identified, its high functional connectivity established, and its components dissociated in order to better understand the interactive and specialized internal mechanisms of that network. (C) 2007 Elsevier Inc. All rights reserved.