Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons
Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons
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DOI：
10.1016/j.neures.2007.09.012
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Matsui, Hideki
中科院分区：
文献类型：
--
作者：
Han, Xiao-Jian;Lu, Yun-Fei;Matsui, Hideki
线粒体形态和运动的改变影响神经元的活力。然而，这种改变的确切机制尚不清楚。在这项研究中，我们发现钙调神经磷酸酶参与调节线粒体动力学。谷氨酸刺激抑制神经元线粒体运动，减少线粒体长度。FK 506和环孢素A，钙调磷酸酶抑制剂，减弱谷氨酸对线粒体动力学的影响。还发现谷氨酸处理使促凋亡蛋白Bad去磷酸化，并通过钙调磷酸酶促进其易位到神经元中的线粒体。这些结果提供了重要的细胞内信号转导途径，调节线粒体动力学和神经元细胞死亡的新见解。(c)2007 Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.