Polymorphism of the human ABO-secretor locus (FUT2) in four populations in Asia:: indication of distinct Asian subpopulations
Polymorphism of the human ABO-secretor locus (FUT2) in four populations in Asia:: indication of distinct Asian subpopulations
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DOI：
10.1017/s0003480001008788
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发表时间：
2001-09-01
影响因子：
1.9
通讯作者：
Kimura, H
中科院分区：
文献类型：
--
作者：
Pang, H;Koda, Y;Kimura, H
人类ABO分泌基因座（FUT 2或Se）的多态性等位基因表现出高度异质性和明显的种族特异性。为了提供更多的数据分析，以阐明人口的起源，我们调查了40个无关的藏族和53个来自尼泊尔的塔芒人，42个来自泗水的印度尼西亚人，和55个来自乌鲁木齐的维吾尔族人的FUT 2等位基因多态性，使用DNA测序。在藏族、塔芒族和印度尼西亚族中，只有亚洲人才有的无功能等位基因se（357，385）的频率分别为0.638、0.509和0.631。在维吾尔族中，高加索人常见的Se 418 1和由两个常见的无功能FUT 2等位基因组成的Se 351、181的频率分别为0.3和0.145。本研究中的四个种群和我们以前研究的六个种群之间的固定指数（F-ST）是基于遗传分化的。结果表明，藏族、塔芒族、印尼族和东亚族之间的遗传分化程度很低，维吾尔族FUT 2等位基因的分布特征显示了欧亚混血的特征。在FUT 2基因座的非功能性等位基因的分布提供了亚洲人群中的人类迁移的进一步证据。
The polymorphic alleles of the human ABO-Secretor locus (FUT2 or Se) show high heterogeneity and overt ethnic specificity. To provide additional data for analysis to elucidate the origins of populations, we have investigated the allelic polymorphism of FUT2 in 40 unrelated Tibetan and 53 Tamang individuals from Nepal, 42 Indonesian individuals from Surabaya, and 55 Uygur individuals from Urumqi, using DNA sequencing. In Tibetan, Tamang and Indonesian populations, the frequency of a nonfunctional allele, se(357,385) which is found only in Asian populations, was 0.638, 0.509 and 0.631, respectively. In Uygur, the se 418 1 which is common in Caucasian populations, and the Se 351,181 consisting of two common nonfunctional FUT2 alleles, had frequencies of 0.3 and 0.145 respectively. The fixation index (F-ST) based on genetic differentiation was obtained pairwise among the four populations in this study and six populations in our previous studies. The results suggested that genetic differentiation among Tibetan, Tamang, Indonesian and East Asian populations is very low, while the distribution feature of the FUT2 alleles in the Uygur population implied an admixture of European with Asian. The distribution of nonfunctional alleles at the FUT2 locus provided further evidence of human migration among the Asian populations.