Therapeutic hypothermia: critical review of the molecular mechanisms of action.
Therapeutic hypothermia: critical review of the molecular mechanisms of action.
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DOI：
10.3389/fneur.2011.00004
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发表时间：
2011
影响因子：
3.4
通讯作者：
López-Meza EG
中科院分区：
文献类型：
--
作者：
González-Ibarra FP;Varon J;López-Meza EG
治疗性低温（TH）是当今最重要的神经保护方法之一。缺血发作后发生的事件是多方面的，体温过低会影响这一级联反应的各个步骤。TH的作用机制是多种多样的，这种疗法的益处的可能解释可能是在许多水平上阻断缺血级联的多种作用机制。TH可影响多种代谢途径、炎症反应、凋亡过程，促进神经元的完整性。了解TH的作用机制将使我们更好地了解这种疗法的适应症，并且当与低温联合使用时，寻找其他疗法的可能性将提供治疗协同效应。
Therapeutic hypothermia (TH) is nowadays one of the most important methods of neuroprotection. The events that occur after an episode of ischemia are multiple and hypothermia can affect the various steps of this cascade. The mechanisms of action of TH are varied and the possible explanation for the benefits of this therapy is probably the multiple mechanisms of action blocking the cascade of ischemia on many levels. TH can affect many metabolic pathways, reactions of inflammation, apoptosis processes, and promote neuronal integrity. To know the mechanisms of action of TH will allow a better understanding about the indications for this therapy and the possibility of searching for other therapies when used in conjunction with hypothermia will provide a therapeutic synergistic effect.