Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task
Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task
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DOI：
10.1152/jn.00949.2002
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发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Wang, WJ
中科院分区：
文献类型：
--
作者：
Compte, A;Constantinidis, C;Wang, WJ
神经科学中的一个重要问题是神经元锋电位序列的时间模式和波动是否以及如何有助于皮层的信息处理。我们已经解决了这个问题，在记忆相关的电路的前额叶皮层的分析尖峰列车从数据库中的229个神经元记录在背外侧前额叶皮层的4只猕猴在执行眼延迟反应任务。对于每个任务时期，我们已经估计了它们的功率谱与峰间期直方图和自相关图。我们发现：1）大多数（约60%）神经元的性质近似泊松过程的特征。对于约25%的细胞，具有典型的中间神经元特征，功率谱在低频处显示出波谷（
An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded in the dorsolateral prefrontal cortex of 4 macaque monkeys during the performance of an oculomotor delayed-response task. For each task epoch, we have estimated their power spectrum together with interspike interval histograms and autocorrelograms. We find that 1) the properties of most (about 60%) neurons approximated the characteristics of a Poisson process. For about 25% of cells, with characteristics typical of interneurons, the power spectrum showed a trough at low frequencies (