Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride
Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride
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DOI：
10.1021/ja0628405
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发表时间：
2006-08-09
影响因子：
15
通讯作者：
Ishihara, Kazuaki
中科院分区：
文献类型：
--
作者：
Hatano, Manabu;Suzuki, Shinji;Ishihara, Kazuaki
以原位生成的氯化锌三烷基锌(II)络合物为催化剂，用格氏试剂高效地催化了酮和乙二胺的烷基化反应。这种简单的锌(II)催化的烷基化反应可以减少仅使用格氏试剂而导致还原和羟醛副产物的严重问题，并可以提高所需的烷基化产物的产率。
A highly efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2(10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products could be improved.