A contemporary research paradigm for the genetic analysis of a common chronic disease.
A contemporary research paradigm for the genetic analysis of a common chronic disease.
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DOI：
10.3109/07853899608999107
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发表时间：
1996
影响因子：
4.4
通讯作者：
E. Boerwinkle
中科院分区：
文献类型：
--
作者：
E. Boerwinkle
Rapid discoveries of novel and unexpected disease-associated genes for atherosclerotic coronary artery disease (CAD) are anticipated as genomic maps become more detailed and methods for mapping complex disease phenotypes become more refined. Although establishing association or linkage of a marker locus to a CAD susceptibility gene is an important first step, the long-term goal should be to define the underlying functional mutations and explore possible disease mechanisms, including the gene-environment interactions that culminate in clinically apparent disease. This review will define a contemporary research paradigm for study of the genetics of CAD and other common chronic diseases, using the tools of modern molecular biology and human genetics.
