Educational History Is an Independent Predictor of Cognitive Deficits and Long-Term Survival in Postacute Patients With Mild to Moderate Ischemic Stroke
Educational History Is an Independent Predictor of Cognitive Deficits and Long-Term Survival in Postacute Patients With Mild to Moderate Ischemic Stroke
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DOI：
10.1161/strokeaha.112.667618
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发表时间：
2012-11-01
期刊：
影响因子：
8.3
通讯作者：
Oksala, Niku
中科院分区：
文献类型：
--
作者：
Ojala-Oksala, Johanna;Jokinen, Hanna;Oksala, Niku
背景和目的--卒中后认知功能下降和脑白质损害(WML)与卒中后存活率低有关。教育史所反映的认知储备是否与认知功能下降、卒中复发和卒中后死亡率无关尚不清楚。方法：共486例急性轻中度缺血性卒中患者在卒中后3个月接受综合神经心理学评估(n=409)和磁共振成像(n=395)，并进行了长达12年的随访。报告了用于Cox回归分析的逻辑比和风险比的优势比(OR和风险比
Background and Purpose-Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known.Methods-A total of 486 consecutive acute mild/moderate ischemic stroke patients subjected to comprehensive neuropsychological assessment (n=409) and magnetic resonance imaging (n=395) 3 months poststroke were included in the study and followed-up for up to 12 years. Odds ratios (OR) for logistic and hazard ratios for Cox regression analyses are reported (OR and hazard ratio