Cutaneous and hemodynamic responses during hot flashes in symptomatic postmenopausal women
Cutaneous and hemodynamic responses during hot flashes in symptomatic postmenopausal women
复制标题
DOI：
10.1097/gme.0b013e3180ca7cfa
复制
发表时间：
2008-03-01
影响因子：
2.7
通讯作者：
Crandall, Craig G.
中科院分区：
文献类型：
--
作者：
Low, David A.;Davis, Scott L.;Crandall, Craig G.
目的：本研究的目的是通过对有症状的妇女的动脉血压和皮肤血管传导性(CVC)的持续测量来评估绝经后潮热伴随动脉血压迅速下降和皮肤血管传导性(CVC)增加的假说。设计：12名健康、血压正常的绝经后妇女在26摄氏度的温控实验室中休息约90分钟。潮热的发生被客观地识别为胸骨出汗率的一过性和显著升高(电容湿度计)。结果：在实验过程中记录到23次潮热(3.4+/-1.4min；范围1.3-6.5min)。在5名受试者的11次潮热中，平均动脉压下降了13.2分钟汞。来自这些被归类为应答者的参与者的数据与那些在潮热期间血压没有变化的参与者的数据被分开分析(n=7，12次潮热)。潮热期间心率(由心电图获得)显著增加，但应答组和无应答组之间没有差异(分别为9+/-2次/分钟和10+/-1次/分钟；P>；0.05)。在前臂(15%+/-3%比12%+/-3%最大CVC，P>；0.05)和胸骨(24%+/-5%比21%+/-3%最大CVC，P>；0.05)组之间CVC的增加没有差异。结论：这些数据表明，在一部分受试者中，潮热伴随着血压的显著下降，但这些女性和没有血压下降的女性之间的CVC没有差异。
Objective: The aim of this study was to test the hypothesis that the postmenopausal hot flash is accompanied by rapid decreases in arterial blood pressure and increases in cutaneous vascular conductance (CVC), as evaluated by continuous measurements of these variables in symptomatic women.Design: Twelve healthy, normotensive, postmenopausal women rested in a temperature-controlled laboratory (26 degrees C) for approximately 90 minutes. The onset of a hot flash was objectively identified as a transient and pronounced elevation of sternal sweat rate (capacitance hygrometry).Results: Twenty-three hot flashes were recorded during the experimental sessions (3.4 +/- 1.4 min; range, 1.3-6.5 min). Mean arterial blood pressure decreased 13 2 min Hg during 11 hot flashes in five participants. Data from these participants, categorized as responders, were analyzed separately from data for those participants whose blood pressure did not change during their hot flashes (n = 7, 12 hot flashes). Heart rate (obtained from an electrocardiogram) significantly increased during the hot flashes, but there was no difference between the responder and nonresponder groups (9 +/- 2 vs 10 +/- 1 beats/min, respectively; P > 0.05). The increase in CVC was not different between groups at either the forearm (15% +/- 3% vs 12% +/- 3% maximal CVC, P > 0.05) or sternum (24% +/- 5% vs 21% +/- 3% maximal CVC, P > 0.05).Conclusions: These data demonstrate that in a subset of participants, the hot flash is accompanied by a significant reduction in blood pressure, but there is no difference in CVC between these women and women with no drop in blood pressure.